2759-47-9Relevant academic research and scientific papers
Method for preparing amide compound by photocatalysis of organic amine
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Paragraph 0050-0051, (2021/06/06)
The invention relates to the technical field of organic synthesis, in particular to a method for preparing amide compounds through photocatalysis of organic amine. The preparation method comprises the following steps: mixing tetrahalomethane with a solvent, sequentially adding an amine compound, a catalyst and organic carboxylic acid, performing stirring and reacting under an oxygen-containing atmosphere and an illumination condition, and performing separating and purifying to obtain the amide compound with a structure shown in formulas V-VII. According to the method, the reaction is carried out in the air atmosphere under the illumination condition at room temperature and normal pressure, the reaction condition is mild, the raw material source is wide, the cost is low, the byproduct generated after the reaction is the halogen simple substance, the added value is high, a large amount of waste is avoided, and the method has higher atom economy and environmental friendliness and is beneficial to large-scale production.
Acid/Base-Co-catalyzed Formal Baeyer-Villiger Oxidation Reaction of Ketones: Using Molecular Oxygen as the Oxidant
Liu, Chun-Hua,Wang, Zhuo,Xiao, Li-Yun,Mukadas,Zhu, Dong-Sheng,Zhao, Yu-Long
supporting information, p. 4862 - 4866 (2018/08/24)
A novel acid/base-co-catalyzed formal Baeyer-Villiger oxidation of various ketones using O2 as the sole oxidant under metal-free conditions has been developed for the first time. The reaction tolerates a wide range of ketones and anilines and provides a simple and efficient method for the construction of various amides and isoquinolin-1-ones from the reactions of ketones with anilines in a single step.
Diastereoselective Pd(II)-Catalyzed sp3 C-H Arylation Followed by Ring Opening of Cyclopropanecarboxamides: Construction of anti β-Acyloxy Carboxamide Derivatives
Gopalakrishnan, Bojan,Mohan, Sruthi,Parella, Ramarao,Babu, Srinivasarao Arulananda
, p. 8988 - 9005 (2016/10/17)
The diastereoselective Pd(OAc)2-catalyzed, bidentate ligand-directed sp3 C-H activation/arylation followed by ring opening of cyclopropanecarboxamides, which were assembled from cyclopropanecarbonyl chlorides and bidentate ligands (e.g., 8-aminoquinoline and 2-(methylthio)aniline), has been investigated. The treatment of various cyclopropanecarboxamides with excess amounts of aryl iodides in the presence of the Pd(OAc)2 catalyst, AgOAc and AcOH directly afforded the corresponding multiple β-C-H arylated open-chain carboxamides (anti β-acyloxy amides). This method has led to the construction of several anti β-acyloxy amides that possess vicinal stereocenters with a high degree of stereocontrol with the formation of a new C-O bond and three new C-C bonds. A plausible mechanism for the formation of multiple β-C-H arylated open-chain carboxamides from the Pd-catalyzed, bidentate ligand-directed β-C-H arylation and the ring opening of cyclopropanecarboxamides is proposed based on several control experiments. The observed diastereoselectivity and anti stereochemistry of the β-acyloxy amides were ascertained based on X-ray structural analysis of representative β-acyloxy amides.
Direct amide bond formation from carboxylic acids and amines using activated alumina balls as a new, convenient, clean, reusable and low cost heterogeneous catalyst
Ghosh, Sabari,Mukhopadhyay, Chhanda,Bhaumik, Asim,Mondal, John,Mallik, Amit,Sengupta, Sumita
, p. 3220 - 3229,10 (2020/09/16)
For the first time, we have used activated alumina balls (3-5 mm diameter) for amide synthesis from carboxylic acids (unactivated) and amines (unactivated) under neat reaction conditions that produce no toxic by-products and has the advantages of being low-cost, easily available, heterogeneous, reusable and environmentally benign with no troublesome/hazardous disposal of the catalyst.
Azido-Schmidt reaction for the formation of amides, imides and lactams from ketones in the presence of FeCl3
Yadav,Reddy, B.V. Subba,Reddy, U.V. Subba,Praneeth
, p. 4742 - 4745 (2008/12/21)
Ketones undergo smooth rearrangement with TMSN3 in the presence of FeCl3 under extremely mild conditions to provide the corresponding amides, imides and lactams in good yields with high selectivity. This method is very useful for the preparation of a wide range of amides, imides and lactams from ketones. The use of FeCl3 makes this method simple, convenient and cost-effective.
