27610-97-5Relevant academic research and scientific papers
DIRECT REGIO- AND STEREO-SELECTIVE LITHIATION OF SECONDARY ALLYL AND METHYLALLYL AMINES: A NEW TYPE OF γ-AMINATED ORGANOLITHIUM REAGENTS IN ORGANIC SYNTHESIS
Barluenga, Jose,Foubelo, Francisco,Fananas, Francisco J.,Yus, Miguel
, p. 1524 - 1552 (2007/10/02)
Several secondary allyl and methylallylamines (6) have been regio- and stereo-selectively lithiated with t-butyl-lithium, giving the corresponding sp2 γ-aminated organolithium intermediates (7), which by reaction with electrophiles D2O, Me2S2,
ONE-POT SYNTHESIS OF α,β-UNSATURATED BUTYROLACTAMS FROM ALLYL AMINES
Barluenga, Jose,Fananas, Francisco J.,Foubelo, Francisco,Yus, Miguel
, p. 4859 - 4862 (2007/10/02)
The successive reaction of different allylamines 1 with n-butyl-lithium,t-butyl-lithium, and diethyl carbonate at temperatures ranging between -50 and 20 deg C leads after hydrolysis to the corresponding α,β-unsaturated butyrolactams 3 in an one-pot process.
