276258-99-2

Upstream product

• 276258-98-1 Ethyl 3-[({3'-[(aminocarbothioyl)amino][1,1'-biphenyl]-3-yl}-sulfonyl)amino]-3-phenyl-propanoate 
• 74-88-4 methyl iodide 
• 276258-78-7 ethyl 3-{[(3'-amino[1,1'-biphenyl]-3-yl)sulfonyl]amino}-3-phenyl-propanoate 

Downstream Products

• 426815-84-1 3-[3'-(1H-imidazol-2-ylamino)-biphenyl-3-sulfonylamino]-3-phenyl-propionic acid ethyl ester 
• 276259-00-8 Ethyl 3-[(3'-{[[(2,2-diethoxyethyl)amino](imino)methyl]amino}-[1,1'-biphenyl]-3-yl)sulfonylamino]-3-phenyl-propanoate 

Relevant academic research and scientific papers

NEW BIPHENYL AND BIPHENYL-ANALOGOUS COMPOUNDS AS INTEGRIN ANTAGONISTS

The present invention relates to biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of pharmaceutical compositions for the treatment and prophyl

Biphenyls as potent vitronectin receptor antagonists

Vitronectin receptor (αVβ3) antagonism has been implicated as a mechanism for the treatment of restenosis following balloon angioplasty. In this work we present results from screening of a focused combinatorial library based on a biphenyl moiety. Our SAR studies led to the identification of compounds with subnanomolar activity, selectivity towards the related GPIIbIIIa receptor and functional activity on human smooth muscle cell migration.