27628-46-2Relevant academic research and scientific papers
A Route to 2-Substituted 3-Cyanopyrroles: Synthesis of Danaidal and Suffrutine A
Wiest, Johannes M.,Bach, Thorsten
, p. 6149 - 6156 (2016/07/26)
The title compounds were prepared in a two-step sequence from 4,4-dimethoxybutyronitrile and the respective esters by Claisen condensation and subsequent Paal-Knorr pyrrole synthesis. The sequence could be performed as a one-pot procedure delivering the pyrroles in yields of 47-72% over two steps (13 examples). Intramolecular variants of the method were applied to the total synthesis of danaidal and suffrutine A from the respective trityl-protected ω-amino alkanoates.
Synthesis of 2,3-Dihydro-1H-pyrrolizine-7-carbaldehyde, the Sex Pheromone Danaidal
Roeder, Erhard,Wiedenfeld, Helmut,Bourauel, Thomas
, p. 1645 - 1647 (2007/10/02)
Danaidal (4) can easily be obtained in high yields from ethyl 2,3,5,6-tetrahydro-1H-pyrrolizine-7-carboxylate (1) via sulphur dehydrogenation or MnO2 oxidation, subsequent reduction to dehydrosupinidine (3), and further oxidation to the desired title compound 4.
Antiinflammatory and antiallergic imidazole derivatives
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, (2008/06/13)
Imidazole derivatives of Formula I STR1 wherein AR1 and AR2 each independently represent phenyl optionally substituted by halogen atoms, alkyl groups, or alkoxy groups, R1 is pyrrolyl, indolyl, imidazolyl, or thiazolyl, all of which are optionally substituted by lower alkyl, free or esterified carboxy or carboxyalkyl groups, benzyl, or benezenesulfonyl; and R2 is hydrogen, lower alkyl, haloalkyl, or a methylene, dimethylene, trimethylene, or tetramethylene group linked to the nitrogen atom of R1, and the physiologically acceptable salts thereof with acids, and when R1 is substituted by carboxy, also the physiologically acceptable salts thereof with bases, are pharmacologically effective compounds, e.g., as antiinflammatories.
