27675-39-4Relevant academic research and scientific papers
Erythrina Alkaloid Analogues as nAChR Antagonists-A Flexible Platform for Leads in Drug Discovery
Clementson, Sebastian,Matheu, Sergio Armentia,R?rsted, Emil M?rcher,Pedersen, Henrik,Jensen, Anders A.,Clausen, Rasmus P.,Vital, Paulo,Glibstrup, Emil,Jessing, Mikkel,Kristensen, Jesper L.
, p. 8248 - 8262 (2021)
Erythrina alkaloids and their central nervous system effects have been studied for over a century, mainly due to their potent antagonistic actions at β2-containing nicotinic acetylcholine receptors (nAChRs). In the present work, we report a synthetic approach giving access to a diverse set of Erythrina natural product analogues and present the enantioselective total synthesis of (+)-Cocculine and (+)-Cocculidine, both found to be potent antagonists of the β2-containing nAChRs.
