2768-55-0

Usage

Uses

Used in Biochemical Research:
Z-SER-LEU-OH DCHA is used as a model compound for studying peptide bond cleavage and enzymatic reactions, providing insights into the mechanisms of these processes and aiding in the development of new biochemical techniques and methodologies.
Used in Drug Development:
Z-SER-LEU-OH DCHA is used as a building block in the design of peptide-based pharmaceuticals and therapeutics, leveraging its stable chemical properties and structural simplicity to create novel and effective treatments for various diseases and conditions.
Used in Biomaterial Development:
Z-SER-LEU-OH DCHA is used in the development of novel biomaterials, potentially enhancing the properties of these materials and expanding their applications in various fields, such as tissue engineering and regenerative medicine.
Used in Investigating Structure-Function Relationships:
Z-SER-LEU-OH DCHA is used as a tool for investigating the structure-function relationships of peptides in biological systems, contributing to a deeper understanding of peptide behavior and its implications in biological processes and therapeutic applications.

Upstream product

• 88962-48-5 N-Benzyloxycarbonyl-L-seryl-L-leucin-cholinester-bromid 
• 61-90-5 L-leucine 
• 71930-50-2 Z-Ser-OSu 
• 88962-23-6 Leucin-2-bromethylester-hydrochlorid 
• 88962-29-2 N-Benzyloxycarbonyl-L-seryl-L-leucin-2-bromethylester 
• 1145-80-8 N-(benzyloxycarbonyl)-L-serine 

Downstream Products

• 700372-65-2 Z-Val-Ser-Leu-[methyl (3RS,4RS)-3,4-epoxypiperidine-3-carboxylate] 
• 700372-71-0 (S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-hydroxy-propionylamino]-4-methyl-pentanoic acid 
• 88962-53-2 N-Benzyloxycarbonyl-L-seryl-L-leucyl-L-alanin-2-bromethylester 
• 88962-54-3 N-Benzyloxycarbonyl-L-seryl-L-leucyl-L-phenylalanin-2-bromethylester 
• 6665-16-3 Ser-Leu-OH 

Relevant academic research and scientific papers

Proteasome inhibitors: Synthesis and activity of arecoline oxide tripeptide derivatives

We describe the synthesis and biological activities of a series of methyl 3,4-epoxypiperidine-3-carboxylate tripeptide derivatives that inhibit the chymotryptic and tryptic active sites of the 20S proteasome. Of the series, compound 2 which contains 3-hydroxy-2-methylbenzoyl group at its N-terminal position, displayed the greatest inhibitory potency (IC50 1 μM). All derivatives showed favourable pharmacokinetic properties.

Glycopeptide Synthesis: Selective C-terminal Deblocking and Peptide Chain Elongation of Glucosylserine Derivatives

Benzyloxycarbonyl-(Z-)serine 2-bromoethyl ester (3b) reacts with 2,3,4,6-tetra-O-benzoyl-α-D-glucopyranosyl bromide (14) to give the glucosylserine ester 15.After conversion into the corresponding 2-iodoethyl ester 23 the carboxylic group is deblocked selectively by reductive elimination using zinc.In this procedure the Z and the carbohydrate protective functions as well as the sensitive O-glycoside bond remain unaffected.The glycosylserine 24 is condensed with amino acid 2-bromoethyl esters 2 to form protected glycodipeptide 2-bromoethyl esters 18 which are extended to give glycotripeptide esters 25 after selective carboxyl deblocking.Whereas protected serine dipeptides 5 are glycosylated with 14 to form the conjugates 18, the glycosylation of the serine tripeptides 10 was not successful.