276862-76-1 Usage
Description
(3S,4S)-Pyrrolidine-3,4-diol hydrochloride, a derivative of the amino acid proline, is a chemical compound with the molecular formula C4H10NO2Cl. It is a white crystalline powder that is soluble in water and has a molecular weight of 136.57 g/mol. (3S,4S)-Pyrrolidine-3,4-diol hydrochloride is known for its antioxidant and anti-inflammatory properties and has been studied for its potential therapeutic applications in various diseases such as cancer, diabetes, and cardiovascular disorders. Furthermore, it is utilized as a chiral auxiliary in asymmetric synthesis and may have potential applications in the development of pharmaceuticals and biologically active compounds.
Uses
Used in Organic Synthesis and Chemical Research:
(3S,4S)-Pyrrolidine-3,4-diol hydrochloride is used as a key intermediate in organic synthesis for the preparation of various chemical compounds. Its unique structure and properties make it a valuable building block in the synthesis of complex organic molecules.
Used in Pharmaceutical Development:
(3S,4S)-Pyrrolidine-3,4-diol hydrochloride is used as a chiral auxiliary in asymmetric synthesis, which is crucial for the development of enantiomerically pure pharmaceuticals. Its ability to induce chirality in the synthesis process helps in the production of single enantiomers with desired biological activities, thereby improving the efficacy and safety of drugs.
Used in Antioxidant and Anti-inflammatory Applications:
Due to its antioxidant and anti-inflammatory properties, (3S,4S)-Pyrrolidine-3,4-diol hydrochloride is being studied for its potential therapeutic applications in various diseases. Its ability to neutralize free radicals and reduce inflammation may contribute to the prevention and treatment of conditions such as cancer, diabetes, and cardiovascular disorders.
Used in the Development of Biologically Active Compounds:
(3S,4S)-Pyrrolidine-3,4-diol hydrochloride may have potential applications in the development of biologically active compounds, such as peptides, proteins, and other biomolecules. Its unique structure and properties can be utilized to design and synthesize novel bioactive compounds with potential applications in medicine, agriculture, and other fields.
Check Digit Verification of cas no
The CAS Registry Mumber 276862-76-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,7,6,8,6 and 2 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 276862-76:
(8*2)+(7*7)+(6*6)+(5*8)+(4*6)+(3*2)+(2*7)+(1*6)=191
191 % 10 = 1
So 276862-76-1 is a valid CAS Registry Number.
InChI:InChI=1/C4H9NO2.ClH/c6-3-1-5-2-4(3)7;/h3-7H,1-2H2;1H/t3-,4-;/m0./s1
276862-76-1Relevant articles and documents
Neladenoson Bialanate Hydrochloride: A Prodrug of a Partial Adenosine A1 Receptor Agonist for the Chronic Treatment of Heart Diseases
Meibom, Daniel,Albrecht-Küpper, Barbara,Diedrichs, Nicole,Hübsch, Walter,Kast, Raimund,Kr?mer, Thomas,Krenz, Ursula,Lerchen, Hans-Georg,Mittendorf, Joachim,Nell, Peter G.,Süssmeier, Frank,Vakalopoulos, Alexandros,Zimmermann, Katja
supporting information, p. 728 - 737 (2017/05/26)
Adenosine is known to be released under a variety of physiological and pathophysiological conditions to facilitate the protection and regeneration of injured ischemic tissues. The activation of myocardial adenosine A1 receptors (A1Rs) has been shown to inhibit myocardial pathologies associated with ischemia and reperfusion injury, suggesting several options for new cardiovascular therapies. When full A1R agonists are used, the desired protective and regenerative cardiovascular effects are usually overshadowed by unintended pharmacological effects such as induction of bradycardia, atrioventricular (AV) blocks, and sedation. These unwanted effects can be overcome by using partial A1R agonists. Starting from previously reported capadenoson we evaluated options to tailor A1R agonists to a specific partiality range, thereby optimizing the therapeutic window. This led to the identification of the potent and selective agonist neladenoson, which shows the desired partial response on the A1R, resulting in cardioprotection without sedative effects or cardiac AV blocks. To circumvent solubility and formulation issues for neladenoson, a prodrug approach was pursued. The dipeptide ester neladenoson bialanate hydrochloride showed significantly improved solubility and exposure after oral administration. Neladenoson bialanate hydrochloride is currently being evaluated in clinical trials for the treatment of heart failure.
GUANIDINO-SUBSTITUTED QUINAZOLINONE COMPOUNDS AS MC4-R AGONISTS
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Page/Page column 120, (2008/06/13)
A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structure IA, IB, and IC where the values of the variables are defined herein.