276863-64-0Relevant articles and documents
Novel 3-(4-piperidinylthio)-1H-indoles as potent nonopioid orally active central analgesics
Potin, Dominique,Parnet, Veronique,Teulon, Jean-Marie,Camborde, Francoise,Caussade, Francois,Meignen, Joelle,Provost, Daniel,Cloarec, Alix
, p. 805 - 809 (2007/10/03)
A series of 3-(4-piperidinylthio)-1H-indoles was synthesized and evaluated in mice in the phenylbenzoquinone(PBQ)-induced writhing and hot plate tests. Most of these compounds are good analgesics with activities comparable to that of morphine. Among them compound 1i (UP 237-61), which has a strong serotonin binding profile, has an interesting antinociceptive activity which is not reserved by naloxone. (C) 2000 Elsevier Science Ltd. All rights reserved.