27687-13-4Relevant academic research and scientific papers
Discovery and evaluation of a series of 3-acylindole imidazopyridine platelet-activating factor antagonists
Curtin, Michael L.,Davidsen, Steven K.,Heyman, H. Robin,Garland, Robert B.,Sheppard, George S.,Florjancic, Alan S.,Xu, Lianhong,Carrera Jr., George M.,Steinman, Douglas H.,Trautmann, Jeff A.,Albert, Daniel H.,Magoc, Terrance J.,Tapang, Paul,Rhein, David A.,Conway, Richard G.,Luo, Gongjin,Denissen, Jon F.,Marsh, Kennan C.,Morgan, Douglas W.,Summers, James B.
, p. 74 - 95 (2007/10/03)
Studies conducted with the goal of discovering a second-generation platelet-activating factor (PAF) antagonist have identified a novel class of potent and orally active antagonists which have high aqueous solubility and long duration of action in animal m
Development of active center-directed inhibitors against plasmin
Teno,Wanaka,Okada,Tsuda,Okamoto,Hijikata-Okunomiya,Naito,Okamoto
, p. 2340 - 2346 (2007/10/02)
Active center-directed inhibitors of plasmin were designed based on the structure of specific substrates of plasmin and then synthesized. Their effects on plasmin were examined and the structure-inhibitory activity relationship was studied. N(α)-trans-4-A
Development of selective inhibitors against plasma kallikrein
Teno,Wanaka,Okada,Tsuda,Okamoto,Hijikata-Okunomiya,Naito,Okamoto
, p. 2930 - 2936 (2007/10/02)
Specific plasma kallikrein inhibitors were designed and synthesized and their structure-activity relationship was studied. trans-4-Aminomethylcyclohexanecarbonyl(Tra)-lysyl-4-ethoxycarbonylanili de inhibited plasma kallikrein and plasmin with 1C50/s
