27691-16-3Relevant academic research and scientific papers
S-, N-, and Se-difluoromethylation using sodium chlorodifluoroacetate
Mehta, Vaibhav P.,Greaney, Michael F.
, p. 5036 - 5039 (2013)
A simple protocol for the difluoromethylation of thiols is reported using chlorodifluoroacetate as the difluoromethylating agent. This cheap reagent undergoes smooth decarboxylation at 95 C to afford difluorocarbene, which can be trapped with a variety of aromatic and heteroaromatic thiols. The reaction is also effective for the difluoromethylation of heterocyclic nitrogen compounds and phenylselenol.
