27693-39-6

Basic information

• Product Name: (4-amino-phenyl)-pyridin-2-yl-methanone
• Synonyms: (4-amino-phenyl)-pyridin-2-yl-methanone
• CAS NO: 27693-39-6
• Molecular Weight: 198.224
• Mol File: 27693-39-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4-amino-phenyl)-pyridin-2-yl-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-amino-phenyl)-pyridin-2-yl-methanone(27693-39-6)
• EPA Substance Registry System: (4-amino-phenyl)-pyridin-2-yl-methanone(27693-39-6)

Safety Data

• Hazardous Substances Data: 27693-39-6(Hazardous Substances Data)

Upstream product

• 27693-38-5 (4-nitrophenyl)-pyridin-2-yl-methanone 
• 109-06-8 α-picoline 
• 62-53-3 aniline 

Downstream Products

• 109258-61-9 N-methyl-N'-[4-(pyridine-2-carbonyl)-phenyl]-thiourea 
• 147696-54-6 N-[4-(2-Pyridylcarbonyl)phenyl]-3,3-difluoro-2-hydroxy-2-difluoromethyl propionamide 
• 147696-06-8 N-[4-(2-Pyridylcarbonyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide 

Relevant articles and documents

Metal-free oxidative: Para -acylation of unprotected anilines with N-heteroarylmethanes

A selective oxidative para-acylation of unprotected anilines with methyl groups in N-heteroarylmethanes was achieved. This transformation proceeds under mild metal-free reaction conditions to produce the corresponding valuable diarylmethanones in good to high yields, featuring high site-selectivity, high functional-group-tolerance, gram-scale synthesis and easy product-derivation. Preliminary mechanistic studies revealed that the present oxidative para-acylation would take place via a Friedel-Crafts-type process of in situ imines and the steric hindrance might be the key issue for the high regio-selectivity.