27696-37-3

Upstream product

• 129833-51-8 2-chloro-3-methyl-α-isonitrosoacetanilide 
• 29027-17-6 2-chloro-3-methylaniline 
• 129833-53-0 7-chloro-6-methylisatin 

Downstream Products

• 129833-41-6 2-(2-Carboxymethyl-phenoxy)-3-chloro-4-methyl-benzoic acid 
• 129833-26-7 (5-Chloro-6-methyl-9-oxo-9H-xanthen-4-yl)-acetic acid 
• 129833-32-5 3-Chloro-2-iodo-4-methyl-benzoic acid 

Relevant academic research and scientific papers

Potential Antitumor Agents. 61. Structure-Activity Relationships for in Vivo Colon 38 Activity among Disubstituted 9-Oxo-9H-xanthene-4-acetic Acids

Analogues of 9-oxo-9H-xanthene-4-acetic acid (XAA) bearing small, lipophilic 5-substituents are among the most dose-potent compounds yet reported with the capability of causing hemorrhagic necrosis of implanted colon 38 tumors in mice.To further extend structure-activity relationships among this class of compound, a series of XAA derivatives bearing two small lipophilic groups at various positions have been prepared and evaluated.The 5,6-disubstituted compounds in particular show consistently high levels of both dose potency and activity, suggesting this is the optimal configuration among substituted 9-oxo-9H-xanthene-4-acetic acids.The 5,6-dimethyl and 5-methyl-6-methoxy are the most effective analogues, showing in vivo colon 38 activity comparable to that of FAA at 10-15-fold lower doses and superior activity to FAA at the respective optimal doses, and the former has been selected for detailed evaluation.