277300-82-0

Usage

Uses

2,2-Dimethoxyethyl Isocyanide is a reagent in the synthesis of (Z)-acyloxyacrylamides.

Upstream product

• 135393-73-6 (N-formylamino)acetaldehyde dimethyl acetal 

Downstream Products

• 866784-79-4 N-(2,2-dimethoxy-ethyl)-2-(benzoyl-benzylamino)-3,3-dimethyl-thiobutyric acid amide 
• 866784-83-0 N-(2,2-dimethoxy-ethyl)-2-(benzoyl-amino)-3,3-dimethyl-thiobutyric acid amide 
• 956298-90-1 N-((1R)-1-{[(2,2-dimethoxyethyl)amino]carbonothioyl}-2-methylpropyl)-N-[(1S)-1-phenylethyl]benzamide 

Relevant academic research and scientific papers

MCR synthesis of a tetracyclic tetrazole scaffold

Scaffold diversity is key in the ongoing exercise of discovery of novel bioactive compounds using high throughput screening (HTS). Based on the Ugi tetrazole synthesis we have designed novel bi- and tri-cyclic scaffolds featuring interesting pharmacophore

PHYTOSPHINGOSINE DERIVATIVES AS ADJUVANTS IN IMMUNE STIMULATION

The invention relates to phytosphingosine derivatives, suitable as adjuvants in immune stimulation. The invention further relates to pharmaceutical compositions comprising such compounds and the medical use of said compounds and/or compositions in therapeutic or prophylactic methods of immune stimulation in a subject, and for use in the treatment of a disease, for which stimulation of an immune response in a subject produces a therapeutic benefit. The invention further relates to the phytosphingosine derivative as described herein for use as an adjuvant in a method of vaccinating a subject. The invention further relates to the phytosphingosine derivative as described herein for use in stimulating antibody production, stimulating an immune response against infection, stimulating an immune response against a cancer, or preventing and/or treating septic shock. The invention further relates to a method for the manufacture of said derivatives comprising an Ugi-4-component reaction (Ugi-4CR).

A straightforward approach towards thiazoles and endothiopeptides via Ugi reaction

Endothiopeptides can easily be obtained via Ugi reaction using thio acids as acid components. If isonitriles with an acetal group are applied, the endothiopeptides can directly be converted into thiazoles using TMSCl-NaI under microwave irradiation. The Royal Society of Chemistry 2005.