27746-03-8

Basic information

• Product Name: 4-CHLORO-1H-PYRROLE-2-CARBOXYLIC ACID
• Synonyms: 4-Chloropyrrole-2-carboxylicacid
• CAS NO: 27746-03-8
• Molecular Formula: C₅H₄ClNO₂
• Molecular Weight: 145.54
• Mol File: 27746-03-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 361.9 °C at 760 mmHg
• Flash Point: 172.7 °C
• Appearance: /
• Density: 1.577 g/cm³
• Vapor Pressure: 7.17E-06mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-CHLORO-1H-PYRROLE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-1H-PYRROLE-2-CARBOXYLIC ACID(27746-03-8)
• EPA Substance Registry System: 4-CHLORO-1H-PYRROLE-2-CARBOXYLIC ACID(27746-03-8)

Safety Data

• Hazardous Substances Data: 27746-03-8(Hazardous Substances Data)

Usage

General Description

4-CHLORO-1H-PYRROLE-2-CARBOXYLIC ACID is a chemical compound with the molecular formula C5H4ClNO2. It is a chlorinated derivative of pyrrole-2-carboxylic acid, which is commonly used in the synthesis of pharmaceuticals and agrochemicals. 4-CHLORO-1H-PYRROLE-2-CARBOXYLIC ACID is a white solid at room temperature and is soluble in organic solvents. It is widely used as an intermediate in the production of various pharmaceuticals and can also be used in the manufacture of dyes, pigments, and other organic compounds. Additionally, it has been studied for its potential biological activity and pharmacological applications. Overall, 4-CHLORO-1H-PYRROLE-2-CARBOXYLIC ACID has important applications in the pharmaceutical and chemical industries.

InChI:InChI=1/C5H4ClNO2/c6-3-1-4(5(8)9)7-2-3/h1-2,7H,(H,8,9)

Upstream product

• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 
• 72652-31-4 2,2,2-trichloro-1-(4-chloro-1H-pyrrol-2-yl)ethan-1-one 

Downstream Products

• 915229-94-6 (S)-3-[5-(4-chloro-1H-pyrrol-2-yl)-[1,2,4]oxadiazol-3-yl]-piperidine-1-carboxylic acid tert-butyl ester 
• 1196047-05-8 4-chloro-1-(4-chlorobenzyl)-1H-pyrrole-2-carboxylic acid 
• 869634-03-7 4-chloro-1H-pyrrole-2-carbohydrazide 
• 959771-58-5 4-chloro-N-[3-(3-cyano-4-fluorophenyl)prop-2-yn-1-yl]-N-(2,4-dimethoxybenzyl)-1H-pyrrole-2-carboxamide 
• 959771-66-5 5-[(6,7-dichloro-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl]-2-fluorobenzoic acid 
• 915229-95-7 (S)-3-[5-(4-chloro-1H-pyrrol-2-yl)-[1,2,4]oxadiazol-3-yl]-piperidine hydrochloride 
• 1253377-02-4 tert-butyl (2R,5S)-5-[(Z,E)-amino({[(4-chloro-1H-pyrrol-2-yl)carbonyl]oxy}imino)methyl]-2-methylpiperidine-1-carboxylate 
• 959771-56-3 1-{[(4-chloro-1H-pyrrol-2-yl)carbonyl]oxy}pyrrolidine-2,5-dione 

Relevant articles and documents

Biosynthesis of pyrrolylpolyenes in Auxarthron umbrinum

The biosynthesis of the pyrrolylpolyene rumbrin (1) in the fungus Auxarthron umbrinum was elucidated using feeding studies with labelled precursors. Incorporation of stable isotopes from [15N]-proline, [13C]-methionine and [13/

PHENYL-3-{ (3- (1H- PYRROL- 2 -YL) - [1 , 2 , 4] 0XADIAZ0L-5-YL] PIPERIDIN-1-YL}-METHANONE DERIVATIVES AND RELATED COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The present invention provides new compounds of formula (I) as positive allosteric modulators of metabotropic receptors - subtype 5 ("mGluR5") which are useful for the treatment or prevention of central nervous system disorders such as for example, cognitive decline, both positive and negative symptoms in schizophrenia as well as other central or peripheral nervous system disorders in which the mGluR5 subtype of glutamate metabotropic receptor is involved. The invention is also directed to pharmaceutical compounds and compositions in the prevention or treatment of such diseases in which mGluKi is involved. W represents (C4-C7)cycloalkyl, (C3-C7)heterocycloalkyl , (C3-C7)heterocycloalkyl-(C1-C3)alkyl or (C3-C7)heterocycloalkenyl ring; represents a (C5-C7)heteroeycloalkyl, (C5-C7)heterocycloalkeiiyl ring or a heteroaryl group of formula (a), (b), (c), (d), (e), (f), (g), (i). Q denotes a cycloalkyl, an aryl or heteroaryl group of formula (j), (k), (l), (m), (n). A is azo -N=N-, ethyl, ethenyl, ethynyl, -NR8C(=O)-, -NR8C(=O)-O-, -NR8C(=O)-NR9, NR8S(=O)2-, -C(=O)NR8-, -O-C(=O)NR8-, -S-, -S(=O)-, -S(=O)2-, -S(C=O)2NR8-, -C(=0)-0-, -0-C(=0)-, -C(=NR8)NR9-, C(C=NOR8)NR9- , -NR8C(=NOR9)-, =N-0-, -0-N=CH- or a group aryl or heteroaryl of formula, (o), (p), (q), (r), (s), (t), (u), (v), (w), (x). The other substituents are defined in the claims.