27746-16-3

Basic information

• Product Name: 2-(4-(dimethylamino)phenyl)isoindoline-1,3-dione
• Synonyms: 2-(4-(dimethylamino)phenyl)isoindoline-1,3-dione
• CAS NO: 27746-16-3
• Molecular Weight: 266.299
• Mol File: 27746-16-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-(4-(dimethylamino)phenyl)isoindoline-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-(dimethylamino)phenyl)isoindoline-1,3-dione(27746-16-3)
• EPA Substance Registry System: 2-(4-(dimethylamino)phenyl)isoindoline-1,3-dione(27746-16-3)

Safety Data

• Hazardous Substances Data: 27746-16-3(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 99-98-9 4-amino-N,N-dimethylaniline 
• 19336-90-4 N-(4-dimethylamino-phenyl)-phthalamic acid 
• 122679-47-4 phthalan-1,3-dione-bis-(4-dimethylamino-phenylimine) 
• 613-73-0 1,2-phenylenediacetonitrile 
• 50-00-0 formaldehyd 
• 21835-60-9 2-(4-aminophenyl)isoindoline-1,3-dione 

Relevant articles and documents

Multivariate regression with substituent shift increments. IV. 2-(4-X-phenyl)-1,3-dihydro-2H-isoindole-1,3-diones and 3-(4-X-phenyl)-3,4-dihydro-2H-1,3-benzoxazine-2,4-diones

Two series of para disubstituted benzenes were studied: 2-(4-X-phenyl)-1,3-dihydro-2H-isoindole-1,3-diones (1) and 3-(4-X-phenyl)-3,4-dihydro-2H-1,3-benzoxazine-2,4-diones (2). Their 1H and 13C chemical shifts were correlated with substituent shift increments (SSI) aj and zj, respectively. For 13C chemical shifts, all four zj values, zj, zo, zm, and zp, were used to check the assignment and to find out possible variables for improvement of regression equations. Significant deviations from plain additivity were observed in the case of δH3 and δC3 chemical shifts. This can be explained by changes in diamagnetic anisotropy contribution induced by different twist of 4-substituent from the benzene plane caused by variable substituent in position 1.

INHIBITORS OF IRES-MEDIATED PROTEIN SYNTHESIS

This disclosure relates to inhibitors of IRES-mediated protein synthesis, compositions comprising therapeutically effective amounts of these compounds, and methods of using those compounds and compositions in treating hyperproliferative disorders, e.g., cancers. This disclosure also relates to compositions comprising inhibitors of IRES-mediated protein synthesis and mTOR inhibitors, and to methods of treating cancer by conjoint administration of inhibitors of IRES-mediated protein synthesis and mTOR inhibitors.

Positive graphene by chemical design: Tuning supramolecular strategies for functional surfaces

A diazonium based-arylation reaction was efficiently used for the covalent addition of 4-amino-N,N,N-trimethylbenzene ammonium to stable dispersions of few layer graphene (FLG) yielding an innovative FLG platform with positive charges to immobilize inorganic polyanions. The Royal Society of Chemistry.