27772-89-0

Upstream product

• 186581-53-3 diazomethane 
• 27772-80-1 4-methyl-5-phenyl-3-hydroxyisoxazole 
• 27762-14-7 N-hydroxy-2-(2-phenyl-[1,3]dioxolan-2-yl)-propionamide 
• 4229-44-1 N-methylhydroxyamine hydrochloride 
• 470467-32-4 4,4,4-trichloro-2-methyl-1-phenylbutane-1,3-dione 

Downstream Products

• 73028-26-9 2,4-dimethyl-5-phenyl-isoxazole-3-thione 
• 73028-17-8 3-chloro-2,4-dimethyl-5-phenyl-isoxazolium; chloride 

Relevant academic research and scientific papers

Synthesis of hydroxypyrazoles and 1-methyl-3-isoxazolones via haloform reactions

The synthesis of a new series of hydroxypyrazoles (2a-f) and 2-methyl-3-isoxazolones (3a-d) from the cyclocondensation reaction of trichloromethyl-substituted 1,3-dielectrophiles (1a-f) with dry hydrazine and N-methylhydroxylamine is reported. The regiospecific cyclocondensation took place with the elimination of the trichloromethyl group in a haloform type reaction when acetonitrile under basic medium was used. The structure of compounds 2 and 3 were determined mainly by 1H and 13C NMR spectroscopy.