27773-39-3 Usage
Uses
Used in Pharmaceutical Industry:
Ervamycine is used as an anticancer agent for its potent activity against various types of cancer. It is particularly effective in treating solid malignancies, such as liver, breast, lung, pancreatic, colorectal, and ovarian cancers. The alkaloid modulates several oncological signaling pathways, including JAK/STAT, RAS/RAF/mTOR, TGF-β1/TGF-β1R, VEGF/VEGFR, and CXCL12/CXCR4 axes, exerting inhibitory effects on tumor growth and progression.
Additionally, Ervamycine demonstrates synergistic anticancer effects when combined with conventional chemotherapeutic drugs, enhancing chemo-sensitivity and efficacy in resistant cases.
Used in Drug Delivery Systems:
To overcome the limitations of Ervamycine, such as poor solubility and bioavailability, novel drug delivery systems have been developed. These systems employ various organic and metallic nanoparticles as carriers for Ervamycine delivery, aiming to improve its pharmacokinetics, bioavailability, and therapeutic outcomes. This approach can potentially enhance the efficacy of Ervamycine in cancer treatment and reduce side effects associated with high doses of the drug.
References
Pyuskyulev et al., Collect. Czech. Chem. Commun., 32, 1289 (1967)
Check Digit Verification of cas no
The CAS Registry Mumber 27773-39-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,7,7 and 3 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 27773-39:
(7*2)+(6*7)+(5*7)+(4*7)+(3*3)+(2*3)+(1*9)=143
143 % 10 = 3
So 27773-39-3 is a valid CAS Registry Number.
27773-39-3Relevant academic research and scientific papers
Studies in plant tissue culture. The synthesis and biosynthesis of indole alkaloids
Kutney,Aweryn,Choi,et al.
, p. 3781 - 3795 (2007/10/02)
Studies involving plant tissue cultures of Catharanthus roseus are described. Investigations concerning the propagation of cell lines of this plant for the purposes of producing indole alkaloids within the Corynanthe, Aspdiosperma and Iboga families are presented. The utilization of such tissue culture systems for studies in biosyntheses and isolation of enzymes are also discussed.
