277756-45-3 Usage
General Description
1-Trifluoromethylcyclobutane-1-carboxylic acid is a chemical compound with the molecular formula C6H7F3O2. It is a derivaitve of cyclobutane carboxylic acid and contains a trifluoromethyl group. 1-TRIFLUOROMETHYLCYCLOBUTANE-1-CARBOXYLIC ACID is used in organic synthesis and pharmaceutical research as a building block for creating new molecules with potential biological activity. The trifluoromethyl group can impart unique properties to the molecules it is attached to, making it a valuable tool for drug discovery and development. Additionally, the cyclobutane ring structure adds sterically bulky and strained properties that can influence the reactivity and biological effects of the molecules it is incorporated into.
Check Digit Verification of cas no
The CAS Registry Mumber 277756-45-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,7,7,7,5 and 6 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 277756-45:
(8*2)+(7*7)+(6*7)+(5*7)+(4*5)+(3*6)+(2*4)+(1*5)=193
193 % 10 = 3
So 277756-45-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H7F3O2/c7-6(8,9)5(4(10)11)2-1-3-5/h1-3H2,(H,10,11)
277756-45-3Relevant articles and documents
Selective reactions of 1,1-cycloalkanedicarboxylic acids with SF4. a route to 1,1-bis(trifluoromethyl)cycloalkanes, 1-fluoroformyl-1-(trifluoromethyl)cycloalkanes and 1-(trifluoromethyl)-1-cycloalkanecarboxylic acids
Dmowski, Wojciech,Wolniewicz, Adam
, p. 141 - 146 (2007/10/03)
Six-, five-, four- and three-membered 1,1-cycloalkanedicarboxylic acid (2a-d) were synthesized by alkaline hydrolysis of the corresponding diesters (1a-d) and the reactions of the formers with SF4 were investigated. 1,1-Bis(trifluoromethyl)cycloalkanes (3a-d) were the products of the reactions conducted at 120-150°C while at 30°C 1-fluoroformyl-1-(trifluoromethyl)cycloalkanes (4a-d) were exclusively formed. The latter were isolated as pure compounds or converted in situ into 1-(trifluoromethyl)-1-cycloalkanecarboxylic acids (5a-d).
