27787-59-3

Upstream product

• 83757-08-8 3-benzylthio-5-amino-1,2,4-thiadiazole 
• 2254-88-8 3,5-dichloro-[1,2,4]thiadiazole 

Relevant academic research and scientific papers

HETEROCYCLIC MODULATORS OF PKB

The invention relates to heterocyclic compounds of Formula I and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein Formula (I). The invention also relates to the therapeutic use of such compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

INHIBITORS OF POLO-LIKE KINASES

Compounds that inhibit Plk1, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.