2779-81-9

Usage

InChI:InChI=1/C4H2Cl2N2O/c5-3-1-2(9)4(6)8-7-3/h1H,(H,7,9)

Upstream product

• 6082-66-2 3,4,6-trichloropyridazine 

Downstream Products

• 20733-10-2 4-hydroxypyridazine 
• 499223-49-3 6-chloro-3-(2-cyclopropyl-6-methylphenoxy)-4-pyridazinol 
• 499225-24-0 6-chloro-3-[3-(trifluoromethyl)phenoxy]-4-pyridazinol 
• 499225-46-6 3-(4-tert-butylphenoxy)-6-chloro-4-pyridazinol 

Relevant academic research and scientific papers

Synthesis method of 4,5-dihydroxypyridazine

The invention belongs to the technical field of synthesis of medical compounds, and particularly discloses a synthesis method of 4,5-dihydroxypyridazine. The preparation method comprises the following steps: by taking 3,4,6-trichloropyridazine as a raw material, reacting the raw material with a sodium hydroxide aqueous solution to obtain a compound 2; then, subjecting the compound 2 to palladium carbon hydrochlorination to remove chlorine to obtain a compound 3; reacting the compound 3 with N-chlorosuccinimide to obtain a compound 4; and reacting the compound 4 with a sodium hydroxide aqueous solution to obtain the final product that is 4,5-dihydroxypyridazine. The method has the advantages of cheap and easily available raw materials, convenience in production and easiness in purification, and can be developed into an industrial production method.

Method for preparing 3, 6-dichloropyridazine-4-alcohol

The invention discloses a method for preparing 3, 6-dichloropyridazine-4-alcohol, and belongs to the technical field of pesticide intermediates. The method comprises the steps of taking 3-acetoxy-2, 5-furandione as a raw material, carrying out cyclization reaction on the raw material and hydrazine hydrate, and then carrying out chlorination and deacetylation reaction to obtain 3, 6-dichloropyridazine-4-alcohol. The technical route of the invention is a two-step synthesis method, which comprises the steps of synthesizing 4-acetoxyl-1, 2-dihydropyridazine-3, 6-diketone from 3-acetoxyl-2, 5-furandione serving as a raw material and hydrazine hydrate, reacting the 4-acetoxyl-1, 2-dihydropyridazine-3, 6-diketone with a chlorination reagent in the presence of a catalyst, and acidifying to remove acetyl to obtain the product. According to the method, the process is easy to operate, the raw materials are cheap and easy to obtain, the reaction temperature is low, conditions such as high temperature and high pressure are avoided, the use of a highly toxic chlorine raw material is avoided, the yield of the two-step reaction is 60-85%, and the purity detected by gas chromatography is greater than 98.0%.