278-38-6Relevant academic research and scientific papers
Stereochemistry of the Conversion of 1,3-Chloroalcohols in Alkaline Medium The Chemistry of 1,3-Bifunctional Systems. XXII
Bartok, Mihaly,Felfoeldi, Karoly,Bozoki-Bartok, Gizella
, p. 2173 - 2178 (2007/10/02)
The transformation of isomeric 1,3-Chloroalcohols 1-4, with cyclohexane skeleton, were studied in aqueous solution containing barium hydroxide.As regards the compounds with cis-configuration, 1 gives the oxetane 5 by intramolecular nucleophilic substitution, while 3 gives the unsatured alcohols 7 and 8 by elimination.In the case of the trans-isomers 2 and 4, fragmentation reactions occur in competition with elimination.The main reaction kinetic parameters of the transformations of the four compounds were determined.
