278175-89-6Relevant articles and documents
Scalable synthesis of (+)-2-amino-3-fluorobicyclo[3.1.0]hexane-2,6- dicarboxylic acid as a potent and selective group II metabotropic glutamate receptor agonist
Sakagami, Kazunari,Kumagai, Toshihito,Taguchi, Takeo,Nakazato, Atsuro
, p. 37 - 43 (2007)
We successfully synthesized the potent and selective group II mGluR agonist (+)-1 (MGS0008) via a process incorporating the key step of efficient fluorination of epoxide (±)-5c. This method would be adaptable to large-scale synthesis to produce (+)-1 in m