278177-82-5

Basic information

• Product Name: (R)-N-(2,3-Dichlorophenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide
• Synonyms: (R)-N-(2,3-Dichlorophenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide
• CAS NO: 278177-82-5
• Molecular Weight: 302.08
• Mol File: 278177-82-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-N-(2,3-Dichlorophenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-(2,3-Dichlorophenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide(278177-82-5)
• EPA Substance Registry System: (R)-N-(2,3-Dichlorophenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide(278177-82-5)

Safety Data

• Hazardous Substances Data: 278177-82-5(Hazardous Substances Data)

Upstream product

• 608-27-5 2,3-dichloroaniline 
• 243982-40-3 (S)-3,3,3-trifluoro-2-methyl-2-trimethylsilanyloxy-propionyl chloride 

Downstream Products

• 329927-02-8 (R)-N-[4-{2-nitropyridyl}-6-sulphonyl-2,3,dichlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide 
• 329926-24-1 (R)-N-[4-{2-aminopyrid-6-ylsulphonyl}-2,3-dichlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide 
• 329901-36-2 (R)-N-[2,3-Dichloro-4-(5-methylpyrid-2-ylaminosulphonyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide 
• 329901-61-3 (R)-N-[2,3-Dichloro-4-(2-methoxypyrid-5-ylaminosulphonyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide 
• 329901-32-8 (R)-N-[2,3-Dichloro-4-((R,S)-2-hydroxypropylaminosulphonyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide 
• 329901-75-9 (R)-N-[2,3-dichloro-4-(chlorosulphonyl)phenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide 

Relevant articles and documents

Substituted N-phenyl 2-hydroxy-2-methyl-3,3,3-trifluoropropanamide derivatives which elevate pyruvate dehydrogenase activity

A compound of formula (I) wherein: n is 1 or 2; R 1 is chloro, fluoro, bromo, methyl or methoxy; R 2 is as defined within; R 3 is as defined within; and R 4 is hydrogen or fluoro; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. The use of compounds of formula (I) in the production of an elevation of PDH activity in a warm-blooded animal such as a human being are also described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are detailed. STR1