27833-64-3 Usage
Uses
1. Used in Pharmaceutical Industry:
Loxapine succinate salt is used as a D2/D4-dopamine receptor antagonist and a serotonergic receptor antagonist for the treatment and control of psychotic symptoms in both acute and chronic schizophrenia. It is also used to treat dementia, anxiety neurosis, hostile/aggressive behavior, and psychotic depression.
2. Used in Choleretic Applications:
Loxapine succinate salt is used as a choleretic agent, which is a substance that increases the flow of bile from the liver to the duodenum, aiding in digestion and the elimination of waste products.
3. Used in Inhalation Powder for Bipolar Disorder or Schizophrenia:
An inhalation powder of loxapine (Adasuve?) was recently approved in the United States and the European Union for the acute management of agitation in patients with bipolar disorder or schizophrenia.
4. Used in Branded Medications:
Loxapine succinate salt is used in the formulation of brand name medications such as Loxapine (Mylan) and Loxitane (Watson), which are prescribed for the treatment of various psychiatric conditions.
Toxicity evaluation
Loxapine has antagonistic action on alpha1 adrenergic,
muscarinic, serotonergic, and dopaminergic receptors. It is
thought to change the level of excitability in subcortical
inhibitory areas of the brain by reducing the firing threshold
of some polysynaptic neurons leading to seizure activity.
Anticholinergic effects are also reported with loxapine
intoxication.
Check Digit Verification of cas no
The CAS Registry Mumber 27833-64-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,8,3 and 3 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 27833-64:
(7*2)+(6*7)+(5*8)+(4*3)+(3*3)+(2*6)+(1*4)=133
133 % 10 = 3
So 27833-64-3 is a valid CAS Registry Number.
InChI:InChI=1/C18H18ClN3O.C4H6O4/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18;5-3(6)1-2-4(7)8/h2-7,12H,8-11H2,1H3;1-2H2,(H,5,6)(H,7,8)
