27848-85-7Relevant academic research and scientific papers
Bidentate hydroxyalkyl NHC ligands for the copper-catalyzed asymmetric allylic substitution of allyl phosphates with grignard reagents
Magrez, Magaly,Le Guen, Yann,Basle, Olivier,Crevisy, Christophe,Mauduit, Marc
supporting information, p. 1199 - 1203 (2013/02/25)
Demonstrating their potential: Bidentate alkoxy NHC ligands have been used in the copper-catalyzed asymmetric allylic alkylation of allyl phosphates with Grignard reagents (see scheme). The method provides access to tertiary and quaternary chiral centers with high regio- and enantioselectivity. The system is also applied to the synthesis of chiral E,E-dienes, a key structural motif prevalent in natural products. Copyright
Stereospecific and stereodivergent construction of quaternary carbon centers through switchable directed/nondirected allylic substitution
Breit, Bernhard,Demel, Peter,Studte, Christopher
, p. 3786 - 3789 (2007/10/03)
Selectivity at the flick of a switch: Through 1,3-chirality transfer, a directing/nondirecting leaving group facilitates the stereospecific and stereodivergent construction of quaternary carbon centers by copper-mediated allylic substitution with Grignard
