278594-42-6Relevant articles and documents
2-Amino-2-oxazolines as subtype selective α2 adrenoceptor agonists
Wong, Wai C.,Sun, Wanying,Cui, Weili,Chen, Yuewen,Forray, Carlos,Vaysse, Pierre J.-J.,Branchek, Theresa A.,Gluchowski, Charles
, p. 1699 - 1704 (2007/10/03)
Cyclohexylamino oxazoline I (AGN 190837), an analogue of 2 (Bay a6781), is a potent α2 adrenoceptor agonist. On the basis of a design generated by receptor-ligand modeling, a number of cyclohexyl and norbornyl analogues were synthesized wherein the propyl group of I was replaced by phenylalkyl subsituents. This resulted in compound 6 being an α(2c) selective agonist, as well as 7 and 9 being α(2a)/α(2c) selective.