278598-12-2

Basic information

• Product Name: PIPERIDINE, 1-(4-PIPERIDINYLCARBONYL)-, HYDROCHLORIDE
• Synonyms: PIPERIDINE, 1-(4-PIPERIDINYLCARBONYL)-, HYDROCHLORIDE;Methanone,1-piperidinyl-4-piperidinyl-, hydrochloride (1:1);1-(4-piperidinylcarbonyl)piperidine hydrochloride
• CAS NO: 278598-12-2
• Molecular Formula: C₁₁H₂₀N₂O*ClH
• Molecular Weight: 0
• Mol File: 278598-12-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: PIPERIDINE, 1-(4-PIPERIDINYLCARBONYL)-, HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PIPERIDINE, 1-(4-PIPERIDINYLCARBONYL)-, HYDROCHLORIDE(278598-12-2)
• EPA Substance Registry System: PIPERIDINE, 1-(4-PIPERIDINYLCARBONYL)-, HYDROCHLORIDE(278598-12-2)

Safety Data

• Hazardous Substances Data: 278598-12-2(Hazardous Substances Data)

Usage

General Description

PIPERIDINE, 1-(4-PIPERIDINYLCARBONYL)-, HYDROCHLORIDE is a chemical compound commonly used as a reagent in organic chemistry and as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It is a hydrochloride salt of piperidinylcarbonyl, which is a derivative of piperidine. This chemical is known for its versatile reactivity and is used in the production of various drugs, including antihistamines, analgesics, and antidepressants. It is also used in the manufacturing of pesticides, plasticizers, and rubber chemicals. The compound is a white crystalline powder that is soluble in water and organic solvents. It is important to handle this compound with care and follow proper safety precautions due to its potential hazards.

Upstream product

• 757949-38-5 4-(piperidine-1-carbonyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 4968-87-0 piperidin-1-yl(pyridin-4-yl)methanone 

Relevant articles and documents

Synthesis and in vitro biological evaluation of carbonyl group-containing inhibitors of vesicular acetylcholine transporter

To identify selective high-affinity inhibitors of the vesicular acetylcholine transporter (VAChT), we have interposed a carbonyl group between the phenyl and piperidyl groups of the prototypical VAChT ligand vesamicol and its more potent analogues benzovesamicol and 5-aminobenzovesamicol. Of 33 compounds synthesized and tested, 6 display very high affinity for VAChT (K i, 0.25-0.66 nM) and greater than 500-fold selectivity for VAChT over σ1 and σ2 receptors. Twelve compounds have high affinity (Ki, 1.0-10 nM) and good selectivity for VAChT. Furthermore, 3 halogenated compounds, namely, trans-3-[4-(4-fluorobenzoyl) piperidinyl]-2-hydroxy-1,2,3,4-tetrahydronaphthalene (28b) (Ki = 2.7 nM, VAChT/sigma selectivity index = 70), trans-3-[4-(5-iodothienylcarbonyl) piperidinyl]-2-hydroxy-1,2,3,4-tetrahydronaphthalene (28h) (Ki = 0.66 nM, VAChT/sigma selectivity index = 294), and 5-amino-3-[4-(p-fluorobenzoyl) piperidinyl]-2-hydroxy-1,2,3,4,-tetrahydronaphthalene (30b) (Ki = 2.40 nM, VAChT/sigma selectivity index = 410) display moderate to high selectivity for VAChT. These three compounds can be synthesized with the corresponding radioisotopes so as to serve as PET/SPECT probes for imaging the VAChT in vivo.

COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES

There are provided according to the invention, novel compounds of formula (I)wherein R, R, R, R, Rand Rare as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.