278611-52-2

Upstream product

• 278611-51-1 {(S)-1-(6-Amino-purin-9-ylmethyl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxymethyl}-morpholin-4-yl-phosphinic acid 
• 278611-50-0 (S)-9-[3-(Dimethoxytrityl)oxy-2-(phosphonomethoxy)propyl]adenine 
• 92999-29-6 (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Relevant academic research and scientific papers

An alternative synthesis of HPMPC and HPMPA diphosphoryl derivatives

In (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC) and (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine (HPMPA) with 3-hydroxy functions protected with 4,4′-dimethoxytrityl (DMTr) groups, phosphonate groups were transformed to the morpholides and treated with bis(tributylammonium) diphosphate. Selective cleavage of the DMTr group in the presence of the labile diphosphate residue was achieved in water at pH 2.5. Purification by charcoal adsorption followed by anion exchange chromatography afforded phosphonate-diphosphate compounds (HPMPCpp, HPMPApp).