278780-08-8

Upstream product

• 1118-60-1 3-iminobutyronitrile 
• 13278-67-6 4-(4-methylphenyl)-3-thiosemicarbazide 

Downstream Products

• 278780-12-4 α-butyronitrilo-β-(4-p-tolyl)-3-thiosemicarbazone 
• 129545-25-1 2-(1-(2-oxo-2H-chromen-3-yl)ethylidene)-N-(p-tolyl)hydrazinecarbothioamide 
• 278780-21-5 C₂₃H₂₅N₅O₂S₂ 
• 278780-18-0 α-phenylhydrazono-β-(4-p-tolyl)-3-thiosemicarbazonobutyronitrile 

Relevant academic research and scientific papers

The uses of 4-aryl-3-thiosemicarbazides in heterocyclic synthesis: Synthesis of coumarin, pyrazole, thiazole and thiophene derivatives

The reaction of 4-phenyl-3-thiosemicarbazide derivatives 1a-e with 3-aminoacetonitrile (2) gave the condensed products 3a-e. The reactivity of the latter products toward variety of chemical reagents was studied. Moreover, the reaction of 3b with phenylisothiocyanate; followed by cyclization with α-haloketones 6,7 and 16, gave the thiazole and thiophene derivatives.