278788-60-6

Basic information

• Product Name: (R)-4-Boc-Piperazine-3-carboxylic acid
• Synonyms: 1-BOC-PIPERAZINE-2-(R)-CARBOXYLIC ACID;(R)-PIPERAZINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER;(R)-1-(TERT-BUTOXYCARBONYL)PIPERAZINE-2-CARBOXYLIC ACID;(R)-1-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID;(R)-1-Boc-piperazine-2-carboxylic acid;(R)-4-Boc-Piperazine-3-carboxylicacid;N-Boc-piperazine-2-carboxylic acid;1,2-Piperazinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2R)-
• CAS NO: 278788-60-6
• Molecular Formula: C₁₀H₁₈N₂O₄
• Molecular Weight: 230.26
• Product Categories: pharmacetical;Piperaizine;amino acids
• Mol File: 278788-60-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 243-247 ºC (DEC.)
• Boiling Point: 371.8 °C at 760 mmHg
• Flash Point: 178.6 °C
• Appearance: /
• Density: 1.193 g/cm³
• Vapor Pressure: 1.5E-06mmHg at 25°C
• Refractive Index: 1.495
• Storage Temp.: Refrigerated.
• PKA: 2.90±0.20(Predicted)
• CAS DataBase Reference: (R)-4-Boc-Piperazine-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-Boc-Piperazine-3-carboxylic acid(278788-60-6)
• EPA Substance Registry System: (R)-4-Boc-Piperazine-3-carboxylic acid(278788-60-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• Hazardous Substances Data: 278788-60-6(Hazardous Substances Data)

Usage

Uses

(R)-1-Boc-Piperazine-2-carboxylic Acid is used in preparation of pyridoisoquinolines as VAMT2 inhibitors for the treatment of hyperkinetic disorders.

InChI:InChI=1/C10H18N2O4/c1-10(2,3)16-9(15)12-5-4-11-6-7(12)8(13)14/h7,11H,4-6H2,1-3H3,(H,13,14)/t7-/m1/s1

Upstream product

• 138775-02-7 (2R)-4-[(benzyloxy)carbonyl]-1-[(tert-butoxy)carbonyl]piperazine-2-carboxylic acid 

Downstream Products

• 252990-05-9 1-(tert-butyl) 2-methyl (R)-piperazine-1,2-dicarboxylate 
• 363192-62-5 (2R)-1-(tert-butoxycarbonyl)-4-methylpiperazine-2-carboxylic acid 
• 894801-90-2 (2R)-1-tert-butoxycarbonyl-4-isopropyl-piperazine-2-carboxylic acid 
• 894801-94-6 tert-butyl (2R)-2-[(4-benzylpiperazin-1-yl)carbonyl]piperazine-1-carboxylate 

Relevant articles and documents

FARNESYL PROTEIN TRANSFERASE INHIBITORS

Disclosed are compounds of formula (1.0), wherein R represents a cyclic moiety to which is bound an imodazolylalkyl group; R represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.