278788-67-3

Usage

Also known as

(R)-baclofen

Purpose

Medication used to treat muscle spasticity and spasms

Mechanism of action

Enhances the activity of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in the brain, leading to muscle relaxation and reduced muscle spasticity

Chemical classification

Ester derivative of baclofen, a muscle relaxant and antispasmodic agent that acts on the central nervous system.

Upstream product

• 50-00-0 formaldehyd 
• 278788-66-2 (R)-tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate 

Relevant academic research and scientific papers

1, 7 - DIAZACARBAZOLES AND THEIR USE IN THE TREATMENT OF CANCER

The invention relates to 1, 7-diazacarbazole compounds of Formula (I), (I-a) and (I-b) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chk 1) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

FARNESYL PROTEIN TRANSFERASE INHIBITORS

Disclosed are compounds of formula (1.0), wherein R represents a cyclic moiety to which is bound an imodazolylalkyl group; R represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.