278788-74-2Relevant academic research and scientific papers
Intermolecular Pummerer Coupling with Carbon Nucleophiles in Non-Electrophilic Media
Colas, Kilian,Martín-Montero, Raúl,Mendoza, Abraham
supporting information, p. 16042 - 16046 (2017/11/21)
A new Pummerer-type C?C coupling protocol is introduced based on turbo-organomagnesium amides, which unlike traditional Pummerer reactions, does not require strong electrophilic activators, engages a broad range of C(sp3)-, C(sp2)-, and C(sp)-nucleophiles, and seamlessly integrates with C?H and C?X magnesiation. Given the central character of sulfur compounds in organic chemistry, this protocol allows access to unrelated carbonyls, olefins, organometallics, halides, and boronic esters through a single strategy.
SUBSTITUTED NICOTINAMIDE DERIVATIVES AS KINASE INHIBITORS
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Paragraph 0070; 0071, (2015/06/24)
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
Heterobicyclic thiophene compounds and methods of use
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Page/Page column 59, (2008/06/13)
Compounds of Formula I and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula I and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
FARNESYL PROTEIN TRANSFERASE INHIBITORS
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Page/Page column 39-40, (2010/02/11)
Disclosed are compounds of formula (1.0), wherein R represents a cyclic moiety to which is bound an imodazolylalkyl group; R represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.
