27889-91-4

Upstream product

• 199444-59-2 3-Benzyl-5-nitro-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrimidine-2,4-dione 
• 821795-59-9 1-benzhydryl-3-benzyl-5-nitro-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Benzhydryl as an efficient selective nitrogen protecting group for uracils

Regioselective N-substitution of the less active nitrogen within uracil analogues has been achieved following preliminary N-protection at the more active N-position with a benzhydryl protecting group. This protecting group is stable to concentrated HCl (a

Direct N3 Alkylation of Uracil and Derivatives via N1-[2-(trimethylsilyl)ethoxymethyl] Protection

Protection at N1 position of uracil and uracil analogs as 2-(trimethylsilyl)ethoxymethyl derivatives permits the clean alkylation at N3. These protected uracils are quite stable in a wide range of pH.