279-82-3Relevant academic research and scientific papers
CENTRALLY ACTIVE AND ORALLY BIOAVAILABLE ANTIDOTES FOR ORGANOPHOSPHATE EXPOSURE AND METHODS FOR MAKING AND USING THEM
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Page/Page column 50; 51, (2014/09/03)
In alternative embodiments, the invention provides nucleophilic hydroxyimino- acetamido alkylamine antidotes that cross the blood-brain barrier (BBB) to catalyze the hydrolysis of organophosphate (OP)-inhibited human acetylcholinesterase (hAChE) in the central nerve system (CNS). The hydroxyimino-acetamido alkylamines of the invention are designed to fit within AChE active center gorge dimensions, bind with reasonable affinity, and react with the conjugated phosphate atom in the gorge. The hydroxyimino- acetamido alkylamines of the invention are also designed to possess ionization states that govern affinity and reactivity for the two linked hAChE re-activation steps. In alternative embodiments, the invention provides pumps, devices, subcutaneous infusion devices, continuous subcutaneous infusion devices, infusion pens, needles, reservoirs, ampoules, a vial, a syringe, a cartridge, a disposable pen or jet injector, a prefilled pen or a syringe or a cartridge, a cartridge or a disposable pen or jet injector, a two chambered or multi- chambered pump, a syringe, a cartridge or a pen or a jet injector, comprising a compound of the invention.
Substituted benzothiazole amide derivatives
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, (2008/06/13)
A compound of formula I and a method of treatment of diseases, related to modulation of the adenosine A2 receptor system comprising administering a compound of formula 1to a person in need of such treatment.
REDUCTION OF KETOXIMES WITH THE BICYCLOHEPTANE AND TRICYCLO2,6>HEPTANE STRUCTURES
Ordubadi, M. D.,Pekhk, T. I.,Belikova, N. A.,Rakhmanchik, T. M.,Plate, A. F.
, p. 678 - 683 (2007/10/02)
Only the corresponding primary amines were obtained during the reduction of the oximes of bicycloheptan-2-one and 1-methyl- and 1-ethylbicycloheptan-2-ones with sodium in alcohol, whereas mixtures of primary amines and 3-azabicyclooctanes were formed with lithium aluminium hydride.The yield of the last products increases with inctrease in the reaction temperature.Only primary amines were obtaines during the reduction of the 1-methyl- and 1-ethyltricyclo2,6>heptan-3-ones oximes both with sodium in alcohol and with lithium aluminum hydride.
