27908-36-7 Usage
Uses
Used in Pharmaceutical Development:
Uridine, 5'-(hydrogen 4-morpholinylphosphonate) is used as a building block for the synthesis of nucleotide analogs, which are crucial in the development of antiviral drugs. Its unique structure allows it to potentially inhibit viral replication and serve as a therapeutic agent against viral infections.
Used in Research and Development:
In the scientific community, Uridine, 5'-(hydrogen 4-morpholinylphosphonate) is utilized as a research tool to explore new therapeutic agents for a variety of medical conditions. Its incorporation into molecular structures can provide insights into the mechanisms of action and potential applications in treating diseases at the molecular level.
Used in Drug Design:
Uridine, 5'-(hydrogen 4-morpholinylphosphonate) is employed in drug design as a potential precursor to create novel pharmaceuticals with specific activities against targets such as enzymes or receptors involved in disease processes. Its unique chemical properties may enable the development of drugs with improved efficacy and selectivity.
Used in Biochemical Studies:
Uridine, 5'-(hydrogen 4-morpholinylphosphonate) serves as a subject in biochemical studies aimed at understanding the interactions between nucleic acid analogs and biological systems. This can lead to a better comprehension of how such compounds can be harnessed for therapeutic purposes.
Check Digit Verification of cas no
The CAS Registry Mumber 27908-36-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,9,0 and 8 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 27908-36:
(7*2)+(6*7)+(5*9)+(4*0)+(3*8)+(2*3)+(1*6)=137
137 % 10 = 7
So 27908-36-7 is a valid CAS Registry Number.
27908-36-7Relevant academic research and scientific papers
On the observation of discrete fluorine NMR spectra for uridine 5'-β,γ-fluoromethylenetriphosphate diastereomers at basic pH
Hwang, Candy S.,Kashemirov, Boris A.,McKenna, Charles E.
, p. 5315 - 5319 (2014/06/23)
Jakeman et al. recently reported the inability to distinguish the diastereomers of uridine 5'-β,γ-fluoromethylenetriphosphate (β,γ-CHF-UTP, 1) by 19F NMR under conditions we previously prescribed for the resolution of the corresponding β,γ-CHF-
A P(V)-N activation strategy for the synthesis of nucleoside polyphosphates
Sun, Qi,Gong, Shanshan,Sun, Jian,Liu, Si,Xiao, Qiang,Pu, Shouzhi
, p. 8417 - 8426 (2013/09/24)
A general and high-yielding synthesis of nucleoside 5′-triphosphates (NTPs) and nucleoside 5′-diphosphates (NDPs) from protected nucleoside 5′-phosphoropiperidates promoted by 4,5-dicyanoimidazole (DCI) has been developed. 31P NMR tracing experiments showed that the sequential deprotection and coupling reactions were exceptionally clean. The phosphoropiperidate exhibited superior reactivity to the conventional phosphoromorpholidate toward DCI-promoted NTP/NDP synthesis. The experimental results suggested that the mechanism of DCI activation could be distinctive for NTP and NDP synthesis, depending on the different nucleophilicity of pyrophosphate and phosphate.
