279236-51-0Relevant academic research and scientific papers
NOVEL INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
-
Page/Page column 85-86, (2010/02/12)
Novel compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl-protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel aminooxyamide compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.
Novel farnesyl protein transferase inhibitors as antitumor agents
-
Page 198, (2010/02/07)
Disclosed are novel tricyclic compounds represented by the formula (1.0): and a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising compounds of formula 1.0. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
