279236-79-2

Upstream product

• 930-62-1 2,4-Dimethylimidazole 
• 870-24-6 2-chloroethanamine hydrochloride 

Downstream Products

• 279237-37-5 4-(1,1-dimethylethyl) 1-(phenylmethyl)-2(R)-[[[2-(2,4-dimethyl-1H-imidazol-1-yl)ethyl]amino]carbonyl]-1,4-piperazinedicarboxamide 
• 279237-99-9 4-(1,1-dimethylethyl) 1-(phenylmethyl)-2(R)-[[[2-(2,5-dimethyl-1H-imidazol-1-yl)ethyl]amino]carbonyl]-1,4-piperazinedicarboxamide 

Relevant academic research and scientific papers

PIPERAZINE DERIVATIVES AS FARNESYL PROTEIN TRANSFERASE INHIBITORS

Disclosed are compounds of the formula: wherein R13 represents an imidazole ring; R14 represents a carbamate, urea, amide or sulfonamide group, and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.

NOVEL INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

Novel compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl-protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel aminooxyamide compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.