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27947-41-7

(4-hydroxyphenyl)dimethylphosphine oxide, also known as 4-(dimethylphosphinoyl)phenol, is an organophosphorus compound with the chemical formula C8H11O2P. It is a colorless to pale yellow crystalline solid that is soluble in organic solvents. (4-hydroxyphenyl)dimethylphosphine oxide is characterized by a phenol group (C6H5OH) with a dimethylphosphine oxide group (P(O)(CH3)2) attached to the para position of the phenol. It is used as a reagent in organic synthesis, particularly in the formation of phosphine ligands for transition metal complexes, and as a precursor in the synthesis of various phosphorus-containing compounds. Due to its reactivity and potential applications in chemical research, (4-hydroxyphenyl)dimethylphosphine oxide is an important intermediate in the field of organophosphorus chemistry.

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  • 27947-41-7 Structure

  • Basic information

    1. Product Name: (4-hydroxyphenyl)dimethylphosphine oxide
    2. Synonyms: (4-hydroxyphenyl)dimethylphosphine oxide
    3. CAS NO:27947-41-7
    4. Molecular Formula:
    5. Molecular Weight: 170.148
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 27947-41-7.mol
    9. Article Data: 1

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (4-hydroxyphenyl)dimethylphosphine oxide(CAS DataBase Reference)
    10. NIST Chemistry Reference: (4-hydroxyphenyl)dimethylphosphine oxide(27947-41-7)
    11. EPA Substance Registry System: (4-hydroxyphenyl)dimethylphosphine oxide(27947-41-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 27947-41-7(Hazardous Substances Data)

27947-41-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 27947-41-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,9,4 and 7 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 27947-41:
(7*2)+(6*7)+(5*9)+(4*4)+(3*7)+(2*4)+(1*1)=147
147 % 10 = 7
So 27947-41-7 is a valid CAS Registry Number.

27947-41-7Upstream product

27947-41-7Downstream Products

27947-41-7Relevant articles and documents

Phosphine Oxides (-POMe2) for Medicinal Chemistry: Synthesis, Properties, and Applications

Stambirskyi, Maksym V.,Kostiuk, Tetiana,Sirobaba, Serhii I.,Rudnichenko, Alexander,Titikaiev, Dmytro L.,Dmytriv, Yurii V.,Kuznietsova, Halyna,Pishel, Iryna,Borysko, Petro,Mykhailiuk, Pavel K.

, p. 12783 - 12801 (2021/09/18)

A general practical approach to hetero(aromatic) and aliphatic P(O)Me2-substituted derivatives is elaborated. The key synthetic step was a [Pd]-mediated C-P coupling of (hetero)aryl bromides/iodides with HP(O)Me2. The P(O)Me2 substituent was shown to dramatically increase solubility and decrease lipophilicity of organic compounds. This tactic was used to improve the solubility of the antihypertensive drug prazosin without affecting its biological profile.

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