27957-93-3

Upstream product

• 87-91-2 (R,R)-(+)-Weinsaeure-diethylester 
• 74-88-4 methyl iodide 
• 87-91-2 diethyl (2R,3R)-tartrate 
• 77-78-1 dimethyl sulfate 
• 408332-88-7 Diethyl tartrate 

Downstream Products

• 1224853-82-0 (2R,3R)-1,1,4,4-tetrakis(4-tert-butylphenyl)-2,3-dimethoxybutane-1,4-diol 
• 1224853-83-1 (5R,6R)-5,6-dimethoxy-4,4,7,7-tetraphenyl-N,N-bis((R)-1-phenylethyl)-1,3,2-dioxa-phosphepan-2-amine 
• 94615-10-8 benzyl N-<(2R,3R)-dimethoxy-3-(ethoxycarbonyl)propanoyl>-glycinate 
• 130675-39-7 (3R,4R)-1-<(benzyloxycarbonyl)methyl>-3,4-(dimethoxy)pyrrolidine-2,5-dione 
• 130675-40-0 (3R,4R)-1-carboxymethyl-3,4-(dimethoxy)pyrrolidine-2,5-dione 
• 107291-11-2 (+)-(2S,3S)-1-(benzyloxy)-4-<(tert-butyldimethylsilyl)oxy>-2,3-dimethoxybutane 
• 107291-10-1 (+)-(2S,3S)-4-(benzyloxy)-2,3-dimethoxy-1-butanol 
• 55933-41-0 (+)-(2S,3S)-1,4-Bis(tosyloxy)-2,3-dimethoxybutane 
• 423773-05-1 C₃₂H₃₄O₄P₂ 
• 423773-02-8 C₃₂H₃₂O₄P₂ 

Relevant academic research and scientific papers

Synthesis of α,ω-Bis-Enones by the Double Addition of Alkenyl Grignard Reagents to Diacid Weinreb Amides

An efficient double addition of substituted alkenylmagnesium bromides to bis-Weinreb amides has been developed, giving α,ω-bis-enones that are building blocks for certain drugs and polymers. Furthermore, reliable protocols for the preparation of the requi

Synthesis of β-Lactams by Palladium(0)-Catalyzed C(sp3)?H Carbamoylation

A general and user-friendly synthesis of β-lactams is reported that makes use of Pd0-catalyzed carbamoylation of C(sp3)?H bonds, and operates under stoichiometric carbon monoxide in a two-chamber reactor. This reaction is compatible with a range of primary, secondary and activated tertiary C?H bonds, in contrast to previous methods based on C(sp3)?H activation. In addition, the feasibility of an enantioselective version using a chiral phosphonite ligand is demonstrated. Finally, this method can be employed to synthesize valuable enantiopure free β-lactams and β-amino acids.

A compound, catalyst component and catalyst

The invention discloses a compound with a novel structure. Structural formula of the compound is represented by formula (1), wherein R1, R2, R3, and R4 may be used for representing the same groups or different groups, and are independently selected from s

One-point binding ligands for asymmetric gold catalysis: Phosphoramidites with a TADDOL-related but acyclic backbone

Readily available phosphoramidites incorporating TADDOL-related diols with an acyclic backbone turned out to be excellent ligands for asymmetric gold catalysis, allowing a number of mechanistically different transformations to be performed with good to outstanding enantioselectivities. This includes [2 + 2] and [4 + 2] cycloadditions of ene-allenes, cycloisomerizations of enynes, hydroarylation reactions with formation of indolines, as well as intramolecular hydroaminations and hydroalkoxylations of allenes. Their preparative relevance is underscored by an application to an efficient synthesis of the antidepressive drug candidate (-)-GSK 1360707. The distinctive design element of the new ligands is their acyclic dimethyl ether backbone in lieu of the (isopropylidene) acetal moiety characteristic for traditional TADDOLs. Crystallographic data in combination with computational studies allow the efficiency of the gold complexes endowed with such one-point binding ligands to be rationalized.

Enantioselective gold catalysis: Opportunities provided by monodentate phosphoramidite ligands with an acyclic TADDOL backbone

(Chemical Equation Presented) The tail makes the difference: Removing the isopropylidene acetal unit from well-known TADDOL ligands improved the performance of the derived phosphoramidite ligands in asymmetric gold catalysis (see scheme; Ts=4-toluenesulfonyl). X-ray crystallography showed that the binding pocket has an effective three-fold symmetry, with through-space interactions between the arene rings of the ligand and the gold center.

A Synthetic Approach to (-)-Quassimarin Based on Intramolecular Diels-Alder Strategy

A novel approach to the tetracyclic precursor 32 for the total synthesis of (-)-quassimarin based on an intramolecular Diels-Alder strategy is described.The key tricyclic species 22 was constructed from the triene 6 via a highly endo-selective intramolecu

Veretherungen von Diolen, Triolen und Hydroxycarbonsaeurederivaten ueber Thallium(I)-alkoholate. Eine neue Variante der Williamson-Reaktion

The etherifications listed in tables 1 and 2 are achieved by converting hydroxy-derivatives, which contain additional oxygen functions, into thallium(I) alkoxides with thallium ethoxide, and treatment with haloalkanes.The scope and limitations of the method are discussed.