279670-90-5Relevant academic research and scientific papers
Synthesis, DNA-binding, and antiviral activity of certain pyrazolo[3,4- d]pyrimidine derivatives
El-Bendary,Badria
, p. 99 - 103 (2000)
Some new pyrazolo[3,4-d]pyrimidine derivatives have been prepared and tested for their antiviral and DNA-binding activities. Compounds 4, 5, and 6 showed high binding affinity to DNA at concentrations of 19, 27, and 28 μg/ml, respectively. On the other hand, compounds 6 and 10 reduced the number of viral plaques of Herpes simplex type-1 (HSV-1) by 66 and 41%, respectively. The detailed synthesis and spectroscopic and biological data are reported.
