279674-87-2Relevant academic research and scientific papers
A divergent synthesis of D- and L-carbocyclic 4′-fluoro-2′,3′-dideoxynucleosides as potential antiviral agents
Chong, Youhoon,Gumina, Giuseppe,Chu, Chung K.
, p. 4853 - 4875 (2000)
D- and L-Carbocyclic 4′-fluoro-2′,3′-dideoxynucleosides have been synthesized from 2, which can be conveniently prepared from 1,2:5,6-di-O-isopropylidene-D-mannitol 1 in eight steps. Ruthenium-catalyzed ring-closing metathesis has been employed in the syn
Stereoselective synthesis of carbocyclic L-4′-fluoro-2′,3′-dideoxyadenosine
Gumina, Giuseppe,Chong, Youhoon,Choi, Yongseok,Chu, Chung K.
, p. 1229 - 1231 (2007/10/03)
(Equation presented) L-(1′S,3′S)-9-[3-Fluoro-3-(hydroxymethyl)cyclopentan-1-yl]adenine 15 has been synthesized from ester 2, which can be conveniently prepared from 2,3-isopropylidene-D-glyceraldehyde 1 in six steps. The key ring closure has been accompli
