28004-64-0

Basic information

• Product Name: 2-Amino-5-[3,4-dichlorophenyl]-1,3,4-thiadiazole
• Synonyms: 2-Amino-5-[3,4-dichlorophenyl]-1,3,4-thiadiazole
• CAS NO: 28004-64-0
• Molecular Formula: C₈H₅Cl₂N₃S
• Molecular Weight: 246.12
• Mol File: 28004-64-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-Amino-5-[3,4-dichlorophenyl]-1,3,4-thiadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5-[3,4-dichlorophenyl]-1,3,4-thiadiazole(28004-64-0)
• EPA Substance Registry System: 2-Amino-5-[3,4-dichlorophenyl]-1,3,4-thiadiazole(28004-64-0)

Safety Data

• Hazardous Substances Data: 28004-64-0(Hazardous Substances Data)

Usage

Class

Thiadiazole derivatives

Structure

Heterocyclic compound with a central thiadiazole ring and two chlorine atoms attached to a phenyl group

Uses

Primarily used in pharmaceutical research and drug development

Biological activities

Studied for antibacterial, antifungal, anticancer properties, as well as potential use in the treatment of inflammatory and neurological disorders
Target for further investigation and development in medicinal chemistry

Upstream product

• 28036-91-1 3,4-dichlorobenzohydrazide 
• 28036-92-2 N₂-(3,4-dichlorobenzoyl)thiosemicarbazide 
• 6292-74-6 (E)-2-(3,4-dichlorobenzylidene) hydrazinecarbothioamide 

Downstream Products

• 113111-57-2 2-Chloro-5-(3,4-dichloro-phenyl)-[1,3,4]thiadiazole 

Relevant articles and documents

PhI-Catalyzed Intramolecular Oxidative Coupling Toward Synthesis of 2-Amino-1,3,4-Thiadizoles

A highly efficient method for the synthesis of thiadiazole derivatives via intramolecular oxidative coupling of thiosemicarbazide, using the in situ generated hypervalent iodine(III) reagents is developed. The protocol can be carried out smoothly and provides a variety of thiadiazole derivatives in moderate to excellent yields. Graphical Abstract: A highly efficient method for the synthesis of thiadiazole derivatives via PhI-catalyzed intramolecular oxidative coupling of thiosemicarbazide has been developed.

Photoredox catalysis of intramolecular cyclizations with a reusable silica-bound ruthenium complex

Photoredox catalysis with the use of a stable, reusable silica-bound chromophore was applied to the intramolecular cyclization of a series of 2-benzylidenehydrazinecarbothioamides to give 5-phenyl-1,3,4-thiadiazol-2-amines. The catalyst was readily prepar