28004-64-0

Usage

Class

Thiadiazole derivatives

Structure

Heterocyclic compound with a central thiadiazole ring and two chlorine atoms attached to a phenyl group

Uses

Primarily used in pharmaceutical research and drug development

Biological activities

Studied for antibacterial, antifungal, anticancer properties, as well as potential use in the treatment of inflammatory and neurological disorders
Target for further investigation and development in medicinal chemistry

Upstream product

• 28036-91-1 3,4-dichlorobenzohydrazide 
• 6292-74-6 (E)-2-(3,4-dichlorobenzylidene) hydrazinecarbothioamide 
• 28036-92-2 N₂-(3,4-dichlorobenzoyl)thiosemicarbazide 

Downstream Products

• 113111-57-2 2-Chloro-5-(3,4-dichloro-phenyl)-[1,3,4]thiadiazole 

Relevant academic research and scientific papers

PhI-Catalyzed Intramolecular Oxidative Coupling Toward Synthesis of 2-Amino-1,3,4-Thiadizoles

A highly efficient method for the synthesis of thiadiazole derivatives via intramolecular oxidative coupling of thiosemicarbazide, using the in situ generated hypervalent iodine(III) reagents is developed. The protocol can be carried out smoothly and provides a variety of thiadiazole derivatives in moderate to excellent yields. Graphical Abstract: A highly efficient method for the synthesis of thiadiazole derivatives via PhI-catalyzed intramolecular oxidative coupling of thiosemicarbazide has been developed.

Efficient three-component synthesis of N-alkyl-3, 6-diaryl-[1, 2, 4]triazolo[4, 3-b][1, 2, 4]triazin-7-amines under solvent-free condition

A simple, efficient and environment-friendly approach is described for the synthesis of N-alkyl-3, 6-diaryl-[1, 2, 4]triazolo[4, 3-b][1, 2, 4]triazin-7-amines based on three-component reaction between 5-aryl-4H-1, 2, 4-triazole-3, 4-diamine, isocyanide and aldeyhde under solvent-free condition. The products are obtained in moderate to good yields and are in a state of high purity.

Photoredox catalysis of intramolecular cyclizations with a reusable silica-bound ruthenium complex

Photoredox catalysis with the use of a stable, reusable silica-bound chromophore was applied to the intramolecular cyclization of a series of 2-benzylidenehydrazinecarbothioamides to give 5-phenyl-1,3,4-thiadiazol-2-amines. The catalyst was readily prepar

Antihypertensive Thiadiazoles. 1. Synthesis of Some 2-Aryl-5-hydrazino-1,3,4-thiadiazoles with Vasodilator Activity

Some 2-Aryl-5-hydrazino-1,3,4-thiadiazoles have been synthesized and screened for antihypertensive activity.In general, compounds with a 2-substituted phenyl ring had higher activity than their 3- or 4-substituted counterparts or those containing heteroar