2801-54-9Relevant academic research and scientific papers
Asymmetric β-Methylation of l- and d-α-Amino Acids by a Self-Contained Enzyme Cascade
Liao, Cangsong,Seebeck, Florian P.
supporting information, p. 7184 - 7187 (2020/03/17)
This report describes a modular enzyme-catalyzed cascade reaction that transforms l- or d-α-amino acids to β-methyl-α-amino acids. In this process an α-amino acid transaminase, an α-keto acid methyltransferase, and a halide methyltransferase cooperate in two orthogonal reaction cycles that mediate product formation and regeneration of the cofactor pyridoxal-5′-phosphate and the co-substrate S-adenosylmethionine. The only stoichiometric reagents consumed in this process are the unprotected l- or d-α-amino acid and methyl iodide.
