280120-79-8

Upstream product

• 913176-66-6 2-(3-cyano-4-fluoro-phenyl)-4-nitro-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (4-bromo-phenyl)-amide 
• 913176-67-7 4-amino-2-(3-cyano-4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (4-bromo-phenyl)-amide 
• 913176-68-8 5-[6-(4-bromo-phenyl)-7-oxo-3-trifluoromethyl-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl]-2-fluoro-benzonitrile 
• 280119-96-2 [1-(3-cyano-4-fluorophenyl)]-3-trifluoromethyl-4-nitro-pyrazole-5-carboxylic acid 
• 209960-58-7 1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic Acid 
• 280120-78-7 2-fluoro-5-[6-(2'-formyl-biphenyl-4-yl)-7-oxo-3-trifluoromethyl-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl]-benzonitrile 

Relevant academic research and scientific papers

Preparation of 1-(3-aminobenzo[d]isoxazol-5-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective, and efficacious inhibitors of coagulation factor Xa

Previously, potent factor Xa inhibitors were described based on the 1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one bicyclic core and a 4-methoxyphenyl P1 moiety. This manuscript describes 1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one and related bicyclic cores with the 3-