280132-84-5Relevant academic research and scientific papers
Double nucleophilic addition. A new one-pot synthesis of 2-alkyl- and 2- phenyl-5-hydrazinopyridine from pyridine
Zhang, Lin-Hua,Tan, Zhulin
, p. 3025 - 3028 (2000)
A new method for the synthesis of 2-alkyl- and 2-phenyl-5- hydrazinopyridine has been developed. Nucleophilic addition on pyridine by alkyl or phenyl lithium reagents generated a 2-substituted dihydropyridine anion that reacts with di-t-butyl azodicarboxylate to form 2,5-disubstituted dihydropyridine. Conversion of the dihydropyridines to pyridines was achieved by a mild air oxidation. (C) 2000 Elsevier Science Ltd.
