28014-46-2 Usage
Chemical Properties
mp 195-202°C
Originator
Estradurin, Ayerst, US ,1957
Manufacturing Process
3 g of estradiol was dissolved in 75 ml of anhydrous pyridine. The solution was cooled to -10°C, whereupon a solution of 1.1 ml of phosphorus oxychloride in 10 ml of anhydrous pyridine was added with agitation. After the addition, which required 7 minutes, the reaction mixture was kept at -10°C for a further period of 3 hours, and then it was left standing at room temperature for 15 hours. A clear solution thus resulted, to which finely crushed ice was then added. The resulting solution was evaporated in vacuum to dryness. After drying in a vacuum desiccator, 3.8 g of a white powder was obtained. This powder was suspended in 2 ml of pyridine, and 25 ml of 0.5 N sodium hydroxide was added, whereupon a solution was obtained which was then diluted with water to 100 ml.The solution was then dialyzed through a cellophane membrane against 4 liters of water for 10 hours, with stirring. The dialysis was repeated 2 additional times, with fresh amounts of water. To the dialyzed solution there was added 2 ml of 1 N hydrochloric acid, whereupon polyestradiol phosphatewas precipitated as a white bulky precipitate. This was centrifuged off and washed repeatedly with 0.1 N hydrochloric acid. Thereafter it was dried in a vacuum desiccator. The yield was 3 g of polyestradiol phosphate. The analysis shows 0.65% of water, 1.35% of pyridine and 9.3% of phosphorus (calculated on a dry sample).
Brand name
Estradurin (Wyeth).
Therapeutic Function
Estrogen
Safety Profile
Confirmed carcinogen
producing liver tumors. An experimental
teratogen. A drug used in cancer treatment.
When heated to decomposition it emits
toxic fumes of POx. See also ESTRADIOL,
ESTERS, POLYMERS, and
PHOSPHORIC ACID.
Check Digit Verification of cas no
The CAS Registry Mumber 28014-46-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,0,1 and 4 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 28014-46:
(7*2)+(6*8)+(5*0)+(4*1)+(3*4)+(2*4)+(1*6)=92
92 % 10 = 2
So 28014-46-2 is a valid CAS Registry Number.
InChI:InChI=1/C18H24O2.H3O4P/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20;1-5(2,3)4/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3;(H3,1,2,3,4)/t14-,15-,16+,17+,18+;/m1./s1
