280144-98-1

Upstream product

• 280143-19-3 [2-chloro-4-(3-chloro-phenyl)-quinazolin-6-yl]-(4-chloro-phenyl)-methanone 
• 215034-82-5 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-2(1H)-quinazolinone 
• 280143-20-6 2-chloro-4-(3-chlorophenyl)-α-(4-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl)-6-quinazolinemethanol 

Downstream Products

• 776282-69-0 7-[chloro-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-5-(3-chloro-phenyl)-tetrazolo[1,5-a]quinazoline 

Relevant academic research and scientific papers

Farnesyl transferase inhibiting 1,2-annelated quinoline enantiomer

(?)-5-(3-Chlorophenyl)-α-(4-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl)tetrazolo-[1,5-a]quinazoline-7-methanamine and its pharmaceutically acceptable acid addition salts, and the use of such compounds in medicine especially for the treatment of cancer

Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors

A series of (4-chlorophenyl)-α-(1-methyl-1H-imidazol-5-yl) azoloquinolines and -quinazolines was prepared. These compounds displayed potent Farnesyl Protein Transferase inhibitory activity and tetrazolo[1,5-a] quinazolines are promising agents for oral in vivo inhibition.

1,2-annelated quinoline derivatives

This invention concerns compounds of formula the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein ═X1—X2—X3— is a trivalent radical,; >Y1—Y2— is