28029-80-3

Upstream product

• 6610-29-3 4-methylthiosemicarbazide 
• 1484-50-0 desyl bromide 
• 753011-68-6 2-isopropylidenehydrazono-3-methyl-4,5-diphenyl-2,3-dihydro-1,3-thiazol 

Downstream Products

• 27904-08-1 2-(8-hydroxy-quinolin-5-ylazo)-3-methyl-4,5-diphenyl-thiazolium; iodide 
• 27893-89-6 2-(4-dimethylamino-phenylazo)-3-methyl-4,5-diphenyl-thiazolium; iodide 
• 55985-52-9 3-methylamino-4,5-diphenyl-pyrazole 
• 55985-47-2 2-methylamino-5,6-diphenyl-6H-1,3,4-thiadiazine 
• 143541-58-6 5-Methyl-4-{[3-methyl-4,5-diphenyl-3H-thiazol-(2E)-ylidene]-hydrazono}-2-phenyl-2,4-dihydro-pyrazol-3-one 
• 27893-64-7 2-(4-diethylamino-phenylazo)-3-methyl-4,5-diphenyl-thiazolium; iodide 
• 31787-16-3 1-methyl-2-{[(3-methyl-4,5-diphenyl-3H-thiazol-2-ylidene)-hydrazono]-methyl}-naphtho[1,2-d]thiazolium; iodide 
• 31787-15-2 3-methyl-2-{[(3-methyl-4,5-diphenyl-3H-thiazol-2-ylidene)-hydrazono]-methyl}-naphtho[2,1-d]thiazolium; iodide 
• 31787-14-1 3-methyl-2-{[(3-methyl-4,5-diphenyl-3H-thiazol-2-ylidene)-hydrazono]-methyl}-benzothiazolium; iodide 
• 31787-18-5 1,3-bis-(3-methyl-4,5-diphenyl-thiazol-2-yl)-1,2-diaza-trimethinium; iodide 
• 31787-17-4 3-methyl-2-{[(3-methyl-4,5-diphenyl-3H-thiazol-2-ylidene)-hydrazono]-methyl}-4-phenyl-thiazolium; iodide 
• 27904-24-1 2-(2-hydroxy-naphthalen-1-ylazo)-3-methyl-4,5-diphenyl-thiazolium betaine 

Relevant academic research and scientific papers

Cyclocondensations of substituted thiosemicarbazides with 2-bromo-1,2-diphenylethan-1-one

The cyclocondensation of 4-methylthiosemicarbazide with 2-bromo-1,2-diphenylethan-1-one in ethanol afforded isomeric 2-methylamino-5,6-diphenyl-6H-3,4-thiadiazine and 2-hydrazono-3- methyl-4,5-diphenyl-2,3-dihydro-1,3-thiazole. A pyrazole was obtained by cyclocondensation and subsequent desulfurization of the thiadiazine when the reaction was carried out in concentrated hydrochloric acid. A chemical proof of the structures has been provided. The product distribution of the cyclizations strongly depends on the substitution pattern of the starting materials, and the cyclizations of methylthiosemicarbazide with 2-bromo-1,2-diphenylethan-1-one behaved considerably different from that of the analogous reactions of α-bromoacetophenone.