28049-02-7

Basic information

• Product Name: Benzenepropanoic acid, diphenylmethyl ester
• CAS NO: 28049-02-7
• Molecular Formula: C22H20O2
• Molecular Weight: 316.4
• Mol File: 28049-02-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, diphenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, diphenylmethyl ester(28049-02-7)
• EPA Substance Registry System: Benzenepropanoic acid, diphenylmethyl ester(28049-02-7)

Safety Data

• Hazardous Substances Data: 28049-02-7(Hazardous Substances Data)

Upstream product

• 91-01-0 1,1-Diphenylmethanol 
• 501-52-0 3-Phenylpropionic acid 
• 84379-71-5 1,3-dioxoisoindolin-2-yl 3-phenylpropanoate 
• 1104567-97-6 2-(3-phenylpropionyloxy)benzothiazole 
• 124552-55-2 N-(3-phenylpropionyloxy)benzotriazole 
• 179386-76-6 1-(1H-benzotriazol-1-yl)-3-phenylpropan-1-one 
• 5350-57-2 benzophenone hydrazone 

Relevant articles and documents

Facile synthesis of diphenylmethyl esters from 2-diphenylmethoxypyridine using catalytic boron trifluoride·diethyl etherate

A practical method for the direct preparation of diphenylmethyl (DPM) esters from 2-diphenylmethoxypyridine is described. The reaction was readily performed in the presence of a catalytic amount of boron trifluoride-diethyl etherate at room temperature. Using this reaction protocol, various carboxylic acids were converted to DPM esters with high yields. This method is highly effective for the protection of carboxylic acids and the synthesis of DPM esters, and offers a promising approach for facile esterification of a variety of carboxylic acids.

Mechanistic studies of DCC/HOBt-mediated reaction of 3-phenylpropionic acid with benzyl alcohol and studies on the reactivities of 'active ester' and the related derivatives with nucleophiles

Despite of the extensive study for peptide synthesis, DCC-mediated esterification is left still unclear. Therefore, DCC- and DCC/HOBt-mediated reactions of 3-phenylpropionic acid (1) with benzyl alcohol were carried out under several mechanistic considerations. Further, in order to determine the reactivities of the so-called 'active esters' compounds changing the substituents bearing carbonyl and related derivatives group for the purpose of the development of new class of non-symmetry cross-linkers, we have studied the reaction of model compounds, N-(3-phenylpropionyloxy)benzotriazole (6), N-(3-phenylpropionyloxy)phthalimide (7), 3-phenylpropionyloxybenzothiazole (8), and N-(3-phenylpropionyl)benzotriazole (9) with various nucleophiles under similar conditions were carried out for the comparison. It was revealed to exhibit the order of 6>>8>9>7.

Direct atom-efficient esterification between carboxylic acids and alcohols catalyzed by amphoteric, water-tolerant TiO(acac)2

A diverse array of oxometallic species were examined as catalysts for a test direct condensation of benzoic acid and 2-phenylethanol in 1:1 stoichiometry. Besides group IVB MOCl2-XH2O and TiOX 2-xH2O, group VB VOCl2-xTHF and group IVB TiO(acac)2 were found to be the most efficient and water-tolerant catalysts for the test reaction. The new neutral catalytic protocol with the optimal TiO(acac)2 tolerates many stereo/electronic structural variations in both (di)-acid (1°-3° alkyl and aryl) and (di)alcohol (1°, 2° alkyl, and aryl) components with high chemoselectivity.