28049-59-4

Usage

Uses

Used in Organic Synthesis:
1-(2-Chlorophenyl)cyclobutanecarbonitrile is used as a key intermediate in organic synthesis for the preparation of various complex organic molecules. Its unique structure allows for the formation of diverse chemical entities through reactions such as addition, substitution, and rearrangement.
Used in Pharmaceutical Industry:
1-(2-Chlorophenyl)cyclobutanecarbonitrile is used as a building block in the development of pharmaceuticals for treating various diseases. Its presence in the molecular structure can influence the pharmacokinetics and pharmacodynamics of the resulting drug candidates, potentially enhancing their efficacy and safety.
Used in Agrochemical Industry:
1-(2-Chlorophenyl)cyclobutanecarbonitrile is used as a precursor in the synthesis of agrochemicals, such as pesticides and herbicides. Its incorporation into these compounds can contribute to improved control of pests and weeds, thereby increasing crop yields and ensuring food security.
Used in Biological Research:
1-(2-Chlorophenyl)cyclobutanecarbonitrile is used as a research tool in biological studies to investigate its potential as an enzyme inhibitor. Understanding its interactions with biological targets can provide insights into the development of new therapeutic agents and the elucidation of biological pathways.

Upstream product

• 2856-63-5 2-Chlorophenylacetonitrile 
• 109-64-8 1,3-dibromo-propane 

Downstream Products

• 151157-45-8 C₁₁H₁₁ClO₂ 
• 29786-24-1 (<1-(o-Chlorophenyl)cyclobutyl>carbonyl)carbamsaeureethylester 
• 29770-98-7 (<1-(o-Chlorophenyl)cyclobutyl>carbonyl)carbamsaeuremethylester 
• 29770-30-7 (<1-(o-Chlorophenyl)-cyclobutyl>-carbonyl)-harnstoff 
• 29771-01-5 <1-(o-Chlorophenyl)cyclobutyl>carbonylisocyanat 
• 29771-00-4 1-(2-chlorophenyl)cyclobutane-1-carboxamide 

Relevant academic research and scientific papers

Synthesis method of arylcyclobutane compound

The present invention discloses a method for synthesizing an arylcyclobutane compound to 1eq phenylacetonitrile and 1.1eq 1-bromo-3-chloropropane as raw material, N,N- dimethylacetamide as a solvent, plus 2.5eq sodium hydride, under the protection of iner

Oxadiazole Amine Derivative Compounds as Histone Deacetylase 6 Inhibitor, and the Pharmaceutical Composition Comprising the same

The present invention relates to a novel compound having an activity of inhibiting histone deacetylase 6 (HDAC6), an optical isomer thereof or a pharmaceutically acceptable salt thereof, a use thereof for preparation of a drug for treatment, a pharmaceutical composition comprising the same, a treatment method using the composition, and a method for preparing the same. The novel compound, an optical isomer thereof or a pharmaceutically acceptable salt thereof according to the present invention has an activity of inhibiting histone deacetylase 6 (HDAC6), and is effective for preventing or treating HDAC6-related diseases, including infectious diseases; neoplasm; endocrine, nutritional and metabolic diseases; mental and behavior disorders; nerve disorders; eye and adnexa diseases; cardiovascular diseases; respiratory diseases; digestive organ diseases; skin and subcutaneous tissue diseases; musculoskeletal and connective tissue diseases; or congenital malformation, deformation and chromosomal abnormality.COPYRIGHT KIPO 2017

Identification of A Novel Small-Molecule Binding Site of the Fat Mass and Obesity Associated Protein (FTO)

N-(5-Chloro-2,4-dihydroxyphenyl)-1-phenylcyclobutanecarboxamide (N-CDPCB, 1a) is found to be an inhibitor of the fat mass and obesity associated protein (FTO). The crystal structure of human FTO with 1a reveals a novel binding site for the FTO inhibitor and defines the molecular basis for recognition by FTO of the inhibitor. The identification of the new binding site offers new opportunities for further development of selective and potent inhibitors of FTO, which is expected to provide information concerning novel therapeutic targets for treatment of obesity or obesity-associated diseases.